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Genomics Inform > Volume 9(1); 2011 > Article
DOI: https://doi.org/10.5808/gi.2011.9.1.012   
Genetic Association between Eotaxin Genes and Asthma and Its Relationship to Birth Season in Korean Children.
Insung Ahn, Se Eun Bae, Jeong Hee Kim, Byong Kwan Son, Hyeon S Son, Sung Il Cho
1Supercomputing Center, Korea Institute of Science and Technology Information, Daejeon 305-806, Korea.
2Laboratory of Computational Biology & Bioinformatics, Institute of Health and Environment, Graduate School of Public Health, Seoul National University, Seoul 151-742, Korea.
3Interdisciplinary Graduate Program in Bioinformatics, College of Natural Science, Seoul National University, Seoul 151-742, Korea.
4Department of Pediatrics, School of Medicine, Inha University, & Inha Univ. Hospital, Environment Health Center, Incheon 400-712, Korea.
5Department of Epidemiology, Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul 151-742, Korea. hss2003@snu.ac.kr
Abstract
Asthma is a chronic disease associated with airway constriction due to inflammation caused by eosinophils, mast cells, and T lymphocytes, leading to serious chronic illness in children. The eotaxin gene family has been shown to play an important role in the pathogenesis of asthma. We hypothesized that the distinctive variations among the four seasons in Korea may affect the expression of eotaxin polymorphisms, especially in children. We examined the possible effects of birth season (spring, March-May; summer, June-August; fall, September-November; and winter, December-February) on the phenotype of asthma in children. All SNP data sets of the eotaxin-2 and eotaxin-3 genes were collected from 78 asthma patients and 101 controls. Here, we investigated the effects of birth season on the expression of eotaxin-2 and eotaxin-3 in Korean children. Using the HAPLOTYPE procedure with the HTR method in SAS/Genetics, we showed that children born in spring and summer show significant haplotypes in both the eotaxin-2 and eotaxin-3 genes. Thus, the expression of polymorphisms in eotaxin-2 and eotaxin-3 may vary by season.
Keywords: asthma; haplotype; eotaxin; children; Korean


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