Evolutionary Signature of Information Transfer Complexity in Cellular Membrane Proteomes.

Kim,  Jong Min; Kim,  Byung Gee; Oh,  S June

doi:2009.7.2.111

Genomics Inform > Volume 7(2); 2009 > Article

Original Article

Genomics & Informatics 2009;7(2): 111-121.

DOI: https://doi.org/10.5808/gi.2009.7.2.111

Evolutionary Signature of Information Transfer Complexity in Cellular Membrane Proteomes.

Jong Min Kim, Byung Gee Kim, S June Oh

¹School of Chemical and Biological Engineering, College of Engineering, Seoul National University, Seoul 151-742, Korea.
²Department of Pharmacology, College of Medicine and Ubiquitous Healthcare Research Center, Inje University, Busan 614-735, Korea. o@biophilos.org

Abstract

Cell membrane proteins play crucial roles in the cell's molecular interaction with its environment and within itself. They consist of membrane-bound proteins and many types of transmembrane (TM) proteins such as receptors, transporters, channel proteins, and enzymes. Membrane proteomes of cellular organisms reveal some characteristics in their global topological distribution according to their evolutionary positions, and show their own information transfer complexity. Predicted transmembrane segments (TMSs) in membrane proteomes with HMMTOP showed near power-law distribution and frequency characteristics in 6-TMS and 7-TMS proteins in prokaryotes and eukaryotes, respectively. This reaffirms the important roles of membrane receptors in cellular communication and biological evolutionary history.

Keywords: chemoreceptor; G protein-coupled receptor; information transfer complexity; membrane protein topology; seven-transmembrane region; signal transduction; transmembrane protein