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Genomics Inform > Volume 9(3); 2011 > Article
A Visualization Tool for Computational Analysis of DNA Methylation Level Using Bisulfite Sequencing Data.
Hongseok Tae
Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA, The Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405, USA. mbio94@naver.com
Abstract
Methylation of cytosine is a post-synthesis modification that does not affect the primary DNA sequence but greatly influences gene expression level and phenotypes of an organism. As high-throughput sequencing of bisulfite-treated DNA is the most efficient method to identify methylated sites, several tools to map sequencing reads on a reference are available. But tools to visualize and to interpret the methylation level of methylation sites are currently insufficient. Herein, we present a novel tool to visualize the methylation level of CpG sites.
Keywords: visualization; DNA methylation; bisulfite sequencing; epigenetics; MethylDraw
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