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Genomics Inform > Volume 3(3); 2005 > Article
Development of a Knowledge Base for Korean Pharmacogenomics Research Network.
Chan Hee Park, Su Yeon Lee, Yong Jung, Yu Rang Park, Hye Won Lee, Ju Han Kim
Seoul National University Biomedical Informatics (SNUBI), Seoul National University College of Medicine, Seoul 110-799, Korea.
Pharmacogenomics research requires an intelligent integration of large-scale genomic and clinical data with public and private knowledge resources. We developed a web-based knowledge base for KPRN (Korea Pharmacogenomics Research Network, http://kprn.snubi. org/). Four major types of information is integrated; genetic variation, drug information, disease information, and literature annotation. Eighteen Korean pharmacogenomics research groups in collaboration have submitted 859 genotype data sets for 91 disease-related genes. Integrative analysis and visualization of the large collection of data supported by integrated biomedical pathways and ontology resources are provided with a user-friendly interface and visualization engine empowered by Generic Genome Browser.
Keywords: Pharmacogenomics; Alleles; MeSH; PharmGKB; Goldenpath; Genew; Generic Genome Browser
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