Genomics Inform Search

CLOSE


Genomics Inform > Volume 5(4); 2007 > Article
Application of Random Forests to Association Studies Using Mitochondrial Single Nucleotide Polymorphisms.
Yoonhee Kim, Ho Kim
1Department of Biostatistics and Epidemiology, School of Public Health, Seoul National University, Seoul, 151-742, Republic of Korea. hokim@snu.ac.kr
2Inherited Disease Research Branch, NHGRI/NIH, Baltimore, MD 20892, USA.
Abstract
In previous nuclear genomic association studies, Random Forests (RF), one of several up-to-date machine learning methods, has been used successfully to generate evidence of association of genetic polymorphisms with diseases or other phenotypes. Compared with traditional statistical analytic methods, such as chi-square tests or logistic regression models, the RF method has advantages in handling large numbers of predictor variables and examining gene-gene interactions without a specific model. Here, we applied the RF method to find the association between mitochondrial single nucleotide polymorphisms (mtSNPs) and diabetes risk. The results from a chi-square test validated the usage of RF for association studies using mtDNA. Indexes of important variables such as the Gini index and mean decrease in accuracy index performed well compared with chi-square tests in favor of finding mtSNPs associated with a real disease example, type 2 diabetes.
Keywords: association; mtSNPs; Random Forests
TOOLS
Share :
Facebook Twitter Linked In Google+
METRICS Graph View
  • 1,308 View
  • 10 Download
Related articles in GNI


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
FOR CONTRIBUTORS
Editorial Office
Room No. 806, 193 Mallijae-ro, Jung-gu, Seoul 04501, Korea
Tel: +82-2-558-9394    Fax: +82-2-558-9434    E-mail: kogo3@kogo.or.kr                

Copyright © 2024 by Korea Genome Organization.

Developed in M2PI

Close layer
prev next