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Genomics Inform > Volume 16(4); 2018 > Article
DOI: https://doi.org/10.5808/GI.2018.16.4.e25    Published online December 28, 2018.
Circulating HOTAIR RNA Is Potentially Up-regulated in Coronary Artery Disease
Niloofar Avazpour1, Mohammadreza Hajjari1, Saeed Yazdankhah2, Azita Sahni1, Ali Mohammad Foroughmand1
1Department of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2Department of Cardiology, Ahvaz Jundishapur University of Medical Science, Imam Khomeini Hospital, Ahvaz, Iran
Corresponding author:  Mohammadreza Hajjari
Tel: +98-09357528648   Email: Mohamad.hajari@gmail.com, m-hajari@scu.ac.ir
Ali Mohammad Foroughmand
Tel: +98-09161119456   Email: aliforough12@yahoo.com
Received: April 23, 2018   Revised: November 15, 2018   Accepted: December 10, 2018
Abstract
Coronary artery disease (CAD) is one of the leading causes of death and disability all around the world. Recent studies have revealed that aberrantly regulated long non-coding RNA (lncRNA) as one of the main classes of cellular transcript play a key regulatory role in transcriptional and epigenetic pathways. Recent reports have demonstrated circulating long noncoding RNAs in blood can be potential biomarkers for CAD. HOTAIR is one of the most cited lncRNAs with a critical role in initiation and progression of the gene expression regulation. Recent research on the role of the HOTAIR in cardiovascular disease lays the basis for the development of new studies considering this lncRNA as a potential biomarker and therapeutic target in CAD. In this study, we aimed to compare the expression of HOTAIR lncRNA in the blood samples of patients with CAD and control samples. The expression level was examined by semi-quantitative reverse transcriptase polymerase chain reaction technique. Our data show that expression of HOTAIR is up-regulated in blood samples of patients with CAD.
Keywords: coronary artery disease, gene expression, HOTAIR, long noncoding RNA
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