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In silico discovery and evaluation of phytochemicals binding mechanism against human catechol-O-methyltransferase as a putative bioenhancer of L-DOPA therapy in Parkinson disease
Surya Narayan Rath, Lingaraja Jena, Rajabrata Bhuyan, Nimai Charan Mahanandia, Manorama Patri
Genomics Inform. 2021;19(1):e7  Published online February 26, 2021
DOI: https://doi.org/10.5808/gi.20061

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In silico discovery and evaluation of phytochemicals binding mechanism against human catechol-O-methyltransferase as a putative bioenhancer of L-DOPA therapy in Parkinson disease
Genomics & Informatics. 2021;19(1):e7   Crossref logo
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Garcinol prevents hyperhomocysteinemia and enhances bioavailability of L-DOPA by inhibiting catechol-O-methyltransferase: an in silico approach
Medicinal Chemistry Research. 2015;25(1):116-122   Crossref logo
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L-dopa as Substrate for human duodenal catechol-O-methyltransferase and aromaticL-amino acid decarboxylase
Biomedical Chromatography. 1990;4(6):242-244   Crossref logo
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Catechol-O-methyltransferase: characteristics, polymorphisms and role in breast cancer
Drug Discovery Today: Disease Mechanisms. 2012;9(1-2):e41-e46   Crossref logo
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Catechol-O-methyltransferase inhibition protects against 3,4-dihydroxyphenylalanine (DOPA) toxicity in primary mesencephalic cultures: new insights into levodopa toxicity
Neurochemistry International. 2003;42(2):139-151   Crossref logo
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Structural Mechanism of S-Adenosyl Methionine Binding to Catechol O-Methyltransferase
PLoS ONE. 2011;6(8):e24287   Crossref logo
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Substrate stereospecificity and selectivity of catechol-O-methyltransferase for DOPA, DOPA derivatives and α-substituted catecholamines
Biochemical Pharmacology. 1982;31(3):433-437   Crossref logo
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Multipotential Marrow Stromal Cells Transduced to ProduceL-DOPA: Engraftment in a Rat Model of Parkinson Disease
Human Gene Therapy. 1999;10(15):2539-2549   Crossref logo
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In Silico Prediction of the Effects of Nonsynonymous Single Nucleotide Polymorphisms in the Human Catechol-O-Methyltransferase (COMT) Gene
Cell Biochemistry and Biophysics. 2020;78(2):227-239   Crossref logo
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Measuring L-dopa in plasma and urine to monitor therapy of elderly patients with Parkinson disease treated with L-dopa and a dopa decarboxylase inhibitor
Clinical Chemistry. 1993;39(4):629-634   Crossref logo
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