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Functional Modification of a Specific RNA with Targeted Trans-Splicing. |
Young Hee Park, Sung Chun Kim, Byung Su Kwon, Heung Su Jung, Kuchan Kimm, Seong Wook Lee |
Genomics Inform. 2004;2(1):45-52. |
Production of functional CFTR from mutant CFTR mRNA repaired by targeted RNA trans-splicing Production of functional CFTR from mutant CFTR mRNA repaired by targeted RNA trans-splicing Selective regression of cancer cells expressing a splicing variant of AIMP2 through targeted RNA replacement by trans-splicing ribozyme Cancer-selective induction of cytotoxicity by tissue-specific expression of targetedtrans-splicing ribozyme Repair of mutant CFTR mRNA by targeted RNA trans-splicing 930. In Vivo Functional Correction of Hemophilia a Mice Via a Novel Spliceosome-Mediated RNA Trans-Splicing Repair Mechanism Designing Efficient Double RNA trans-Splicing Molecules for Targeted RNA Repair Raa4 is a trans-splicing factor that specifically binds chloroplast tscA intron RNA Enterobius vermicularis: specific detection by amplification of an internal region of 5S ribosomal RNA intergenic spacer and trans-splicing leader RNA analysis. E. vermicularis: specific detection by PCR and SL1 RNA analysis 352. Imaging Trans-Splicing Events in Cells and Living Animals Using the SMaRT™ (Spliceosome Mediated RNA Trans-Splicing) Strategy |